Current Issue : January-March Volume : 2019 Issue Number : 1 Articles : 4 Articles
Mushrooms are essential food as well as functional food. They are naturally enriched with carbohydrates, vitamins, fibres and amino acids. They have been used as a part of medicine in the Western and other countries. Owing to their benefits, they are also termed as medicinal mushrooms which can be defined as basidiomycetes class of macroscopic fungi. Among many medicinalmushrooms, Agaricus blazei, which is a basidiomycete fungus, possesses many medicinal properties. Agaricus blazei Murrill (ABM) is familiar in Japan as Himematsutake, Agarikusutake, or Kawarihiratake. Agaricus blazei Murrill belongs to the kingdom Fungi, Division Basidiomycota, class Agaricomycetes, order Agaricales, Family Agaricaceae and Genus Agaricus. Morphologically ABM possesses small to large fruiting bodies, the colour changes with age from white, yellow and brown piles to chocolate brown and dark-brown. Agaricus blazei possess many medicinal properties such as anti-cancer activity, anti-tumour activity, immune modulatory activity, cytotoxic activity, anti-oxidant activity, anti-viral activity, anti-bacterial activity, anti-diabetic activity, anti-hypertensive activity, anti-thrombotic activity, anti-anaphylaxis andthe fungus is also used as an adjuvant in many diseases....
In-vitro antioxidant studies were carried out by standard methods on leaves and stem extracts of Ventilago maderspatana Gaertn belonging to the family Rhamnaceae. It is an important and well known plant in the Indian system of medicine. Leaf and stem samples of V. maderspatana were subjected to maceration by using distilled water and ethanol. Aqueous and ethanolic extract were prepared from the leaf, stem of Ventilago maderspatana. Ethanolic extract of leaves and stem showed the potent antioxidant activity in comparison with prepared extracts....
In-vitro antioxidant studies were carried out by standard methods on leaves, stem and stem bark extracts of Ziziphus xylopyrus (Retz) Willd. belonging to family Rhamnaceae. It is an important and well known plant in the Indian system of medicine. Leaf, stem and stem bark samples of Ziziphus xylopyrus were subjected to maceration by using distilled water and ethanol. Aqueous and ethanolic extract were prepared from the leaf, stem and stem bark of Ziziphus xylopyrus. Ethanolic extract of leaves, stem and stem bark showed the potent antioxidant activity....
Bioenhancers are the agents capable of enhancing bioavailability of certain drugs with which it is co-administered. Piperine (CAS no:94-62-2), an alkaloid obtained from Piper nigrum and P. longum has been shown to possess diverse biochemical and pharmacological activities and known inhibitor of various enzymes like CYP (Cytochrome P450) responsible for biotransformation of drugs. By inhibiting the metabolism of drugs, piperine improves the bioavailability of drugs. In the present study piperine (10 mg/kg) significantly increased dose-dependent antihyperglycemic activity of metformin (CAS no: 1115-70-4) which was correlated with increased plasma concentration of metformin as evaluated by glucose challenged and alloxan-induced diabetic models, when it was administered with metformin. The increased plasma concentration of metformin when co-administered with piperine may be due to modification in gastrointestinal epithelial cell membrane permeability or inhibition of gastrointestinal transit or gastric emptying time or modifications in intestinal motility or increase in gastrointestinal blood supply, which results in increasing the bioavailability of metformin. The results of this study demonstrate that piperine could be used as a potential bioenhancer along with metformin....
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